Network Partner

Eckardt Treuter Ph.D. Professor Dept of Biosciences and Nutrition, NOVUM Karolinska Institutet S-141 57 Huddinge/Stockholm, Sweden Phone: +46 86089162 e-mail: eckardt.treuter@ki.se Personal web page

Nuclear receptors are a unique family of transcription factors that play a key role in nearly all biological processes, including development, metabolism and reproduction. As these receptors bind hormones, nutritional substances and drugs, they can directly influence gene expression and a variety of intracellular signal pathways.

Better understanding of the molecular interaction between nuclear receptors and their coregulators and ligands in gene regulation is fundamental to better understanding of the signal pathways of nuclear receptors in cancer and other diseases.

• News:
• Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
• GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response